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It currently has over 1,400 reviews and a 4.8 out of 5.0 rating in the US Mac App Store. Amphetamine has been on the Mac App Store since 2014 and it’s been downloaded over 432,800 times.
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Thank you to all for sharing this story and helping to keep Amphetamine in the App Store.Īmphetamine is a free app that helps keep your Mac awake. On that call, an Apple representative stated that Apple now recognizes that the word "amphetamine" and the pill icon are being used "metaphorically", and in a "medical sense." Published by Elsevier B.V.On January 2nd, 2021, I received a call from Apple to discuss the results of my appeal.
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High study drop-out and poor medication adherence limits the strength of evidence and raises important clinical questions about how to improve treatment engagement and outcomes.Īmphetamine Dependence Methamphetamine Pharmacotherapy Treatment.Ĭopyright © 2018. No medicine has as yet demonstrated sufficient, consistent evidence of effectiveness to support its use in routine treatment. Six other medicines indicate the potential for efficacy, but the number of studies is too small to draw conclusions. Four RCTs of dexamphetamine suggest its benefit on secondary outcomes such as treatment retention, but not for reducing amphetamine use. Four of these medicines demonstrated some limited evidence of benefit for reducing amphetamine use: methylphenidate (as reported in three studies), bupropion (in three studies), modafinil (two studies), and naltrexone (one study). Five medications were subject to multiple RCTs.



Of these, 35 studies related to 33 level II quality randomized controlled trials (RCTs). A meta-narrative review approach was used to synthesize results.Ī total of 49 studies investigating 20 potential pharmacotherapies were eligible for inclusion. Studies on medications for amphetamine/methamphetamine dependence treatment were selected and assessed by two independent researchers. Medline, PsycINFO, Embase and the Cochrane Database of Systematic Reviews were searched from 1997 to 2012 and again from 2013 to 2016. This study aimed to identify medicines that have potential in improving treatment outcomes for people who are dependent on amphetamines. Establishing effective pharmacotherapy provides broader treatment options for people who are dependent on amphetamine and may encourage engagement in evidence-based behavioral treatment. Demand for treatment for amphetamine use is increasing internationally.
